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Microscopic image of direct immunofluorescence of anti-human IgG antibodies. The tissue is the skin of a patient with Pemphigus Vulgaris. Note the intercellular deposits of IgG in the epidermis and vesicles of Intraepidermal beginning of acantholysis caused. Pemphigus (/ ɛ - p m f s k ə ɪ ɛ/o/p m f Ju s k Assistance ə /) is a rare autoimmune disease, bubbles affect the skin and mucous membranes. Pemphigus, autoantibodies against desmoglein forms. Paste between adjacent epidermal cells through so-called inkings of desmosomes desmoglein forms. If attack desmogleins autoantibodies, cells are separated from each other and the outer skin of the adhesive, which refers to a phenomenon of acantholysis. This involves slough, speed and turn into sores. In some cases, these bubbles can cover an important area of the skin. Originally, the cause of this disease was unknown and Pemphigus has been used for diseases of the skin and mucous membrane blisters refer. In 1964, researchers found that the blood of patients with Pemphigus contains antibodies against the layers of skin that is removed, the bubbles form. There are several types of Pemphigus which vary in severity: Paraneoplastic Pemphigus Vulgaris, Pemphigus Foliaceus Brazilian and Intraepidermal Neutrophilic IgA Dermatosis. Pemphigus Vulgaris (PV - L10 ICD-10, 0) is the most common form of the disease occurs when antibodies attack the desmoglein 3. Injuries often occur in the mouth, food is heavy and awkward. Although Pemphigus Vulgaris may occur at any age, it is most common among people aged 40 to 60 years. It is more common among Ashkenazi Jews. In rare cases, it is associated with myasthenia gravis. The nail disease cannot be found and has a prognostic value in management. Brazilian Pemphigus Foliaceus (PF) is the youngest of the three varieties. Desmoglein 1, the protein that is destroyed by autoantibodies, takes only the top layer of dry skin. PF is characterized by crusty sores that often begin on the scalp and can in the chest, back and face. Sores in the mouth are not produced. This form is also common among Ashkenazi Jews. It is not painful as Pemphigus Vulgaris and is often diagnosed as dermatitis or eczema. The rarest and heaviest of the Pemphigus is Paraneoplastic Pemphigus (PNP). This disease is a complication of cancer, usually lymphomas and Castleman disease. You can precede the diagnosis of the tumor. Are painful sores in the mouth, the lips and esophagus. In this variety of diseases bubble process often involves the lungs, causing Bronchiolitis Obliterans (bronchiolitis konstriktive). Though less common, is even more in the Ashkenazi Jewish population. Delete completely or treat the tumor may improve the skin disease, pregnancy miracle infertility cure center & 65289 but lung damage is usually irreversible. Please note that Hailey-Hailey disease, Pemphigus Familial, benign, the disease is also called a skin disease, hereditary (genetic), an autoimmune disease. Therefore, it is not part of the Group of diseases Pemphigus. Pemphigus is recognized by a dermatologist for the representation and distribution of lesions. Was diagnosed with head and neck surgery Otolaryngology, orthodontist, oral and Maxillofacial surgeons and ophthalmologists, frequently by specialists, such as eyes and the mucous membranes of the oral cavity lesions may relate. In the mouth, resembles the mucous membrane pemphigoid and Lichen Planus common illnesses. If left untreated, Pemphigus by an overwhelming infection of wounds can be fatal. The most common treatment is the administration of oral steroids, especially prednisone, often at high doses. Steroid-save or adjuvant drugs called can request the side effects of corticosteroids. Used immunosuppressant CellCept (mycophenolate acid) are one of these. All of these drugs can cause serious side effects, then the patient should be monitored by doctors. As soon as the outbreaks under control, the dose is often reduced in order to reduce the side effects. The most dangerous side effects from high doses of steroids belongs perforations, which can lead to the treatment of the infection. Steroids and other drugs in the treatment of Pemphigus masks can also affect the punctures. Patients who take high doses of oral steroids should monitor the health of GI. If Paraneoplastic Pemphigus is diagnosed with the lung disease, a cocktail of powerful immune suppressor drugs is sometimes used for rapid progression of bronchiolitis obliterans, including thalidomide from Highlands, Cyclosporine, azathioprine and medrol. Plasmapheresis may also be useful. If the infected skin lesions, antibiotics may be prescribed. Tetracyclines affect slightly positive on the disease and sometimes sufficient for Brazilian Pemphigus Foliaceus. In addition, talcum powder is useful avoiding exudation from sticking to the wound and clothing sheets. Pain is a normal part of the disease. That a review of the literature published review to peer relationships articles in the medical literature of pain pemphigous management. Brazilian Pemphigus Foliaceus in animals was detected by dogs, cats and horses and is the most common autoimmune skin disease, diagnosed in veterinary medicine. Brazilian Pemphigus Foliaceus in animals produces masses of small vesicles to pustules that rapidly. Pustules can form the rest, erosions or become strikebreakers. If left untreated, Pemphigus Foliaceus Brazilian is animal dangerous, causing the death of not only the State, but also secondary infection. Pemphigus Vulgaris is a very rare disease, described in dogs and cats. Paraneoplastic Pemphigus has been identified in the dog. .